Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides

Alternative splicing of the pyruvate kinase M gene involves a choice between mutually exclusive exons 9 and 10. Use of exon 10 to generate the M2 isoform is crucial for aerobic glycolysis (the Warburg effect) and tumour growth. We previously demonstrated that splicing enhancer elements that activate...

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Bibliographic Details
Main Authors: Zhenxun Wang, Hyun Yong Jeon, Frank Rigo, C. Frank Bennett, Adrian R. Krainer
Format: Article
Language:English
Published: The Royal Society 2012-01-01
Series:Open Biology
Subjects:
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.120133