Role of Caspase-12 in Amyloid β-Peptide-Induced Toxicity in Organotypic Hippocampal Slices Cultured for Long Periods

Amyloid β (Aβ) toxicity has been implicated in cell death in the hippocampus, but its specific mechanisms are poorly understood. In this study, Aβ-induced cell death was investigated in organotypic hippocampal slice cultures (OHCs) that were cultured for various periods in vitro. There were no obvio...

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Main Authors: Kumiko Ishige, Noritaka Takagi, Toru Imai, Wolf Dieter Rausch, Yasuhiro Kosuge, Tetsuroh Kihara, Kuniko Kusama-Eguchi, Hiroko Ikeda, Alexander Rudolf Cools, John Lionel Waddington, Noriaki Koshikawa, Yoshihisa Ito
Format: Article
Language:English
Published: Elsevier 2007-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S134786131934277X