An IKK/NF-κB Activation/p53 Deletion Sequence Drives Liver Carcinogenesis and Tumor Differentiation

An IKK/NF-κB Activation/p53 Deletion Sequence Drives Liver Carcinogenesis and Tumor Differentiation

Background: Most liver tumors arise on the basis of chronic liver diseases that trigger inflammatory responses. Besides inflammation, subsequent defects in the p53-signaling pathway frequently occurs in liver cancer. In this study, we analyzed the consequences of inflammation and p53 loss in liver c...

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Bibliographic Details
Main Authors: Michael Svinarenko, Sarah-Fee Katz, Umesh Tharehalli, Medhanie A. Mulaw, Harald J. Maier, Yoshiaki Sunami, Sarah K. Fischer, Yuexin Chen, Sabine Heurich, Lena Erkert, Andrea Tannapfel, Thomas Wirth, Reinhold Schirmbeck, Thomas Seufferlein, André Lechel
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
inflammation
hepatocellular carcinoma
intrahepatic cholangiocarcinoma
ectopic lymphoid structures
progenitor cells
Online Access:https://www.mdpi.com/2072-6694/11/10/1410

Internet

https://www.mdpi.com/2072-6694/11/10/1410

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