Synonymous mutations make dramatic contributions to fitness when growth is limited by a weak-link enzyme.

Synonymous mutations do not alter the specified amino acid but may alter the structure or function of an mRNA in ways that impact fitness. There are few examples in the literature, however, in which the effects of synonymous mutations on microbial growth rates have been measured, and even fewer for...

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Bibliographic Details
Main Authors: JohnCarlo Kristofich, Andrew B Morgenthaler, Wallis R Kinney, Christopher C Ebmeier, Daniel J Snyder, William M Old, Vaughn S Cooper, Shelley D Copley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-08-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC6128649?pdf=render