Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome

Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome

Down syndrome (DS), trisomy 21, is caused by increased dose of genes present on human chromosome 21 (HSA21). The gene-dose hypothesis argues that a change in the dose of individual genes or regulatory sequences on HSA21 is necessary for creating DS-related phenotypes, including cognitive impairment....

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Bibliographic Details
Main Authors: Alexander M. Kleschevnikov, Jessica Yu, Jeesun Kim, Larisa V. Lysenko, Zheng Zeng, Y. Eugene Yu, William C. Mobley
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Neurobiology of Disease
Subjects:
Down syndrome critical region
Kcnj6
Kir3.2
Genotype-phenotype relationship
Mouse models
Ts65Dn
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117300578

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http://www.sciencedirect.com/science/article/pii/S0969996117300578

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