Design and synthesis of tag-free photoprobes for the identification of the molecular target for CCG-1423, a novel inhibitor of the Rho/MKL1/SRF signaling pathway

Design and synthesis of tag-free photoprobes for the identification of the molecular target for CCG-1423, a novel inhibitor of the Rho/MKL1/SRF signaling pathway

CCG-1423 and related analogues represent a new class of inhibitors of Rho/MKL1/SRF-mediated gene transcription, a pathway that has been implicated in both cancer and fibrosis. The molecular target for these compounds is unknown. To facilitate its identification, a series of tag-free photoaffinity pr...

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Bibliographic Details
Main Authors: Jessica L. Bell, Andrew J. Haak, Susan M. Wade, Yihan Sun, Richard R. Neubig, Scott D. Larsen
Format: Article
Language:English
Published: Beilstein-Institut 2013-05-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
CCG-1423
click ligation
photoaffinity labeling
Rho pathway inhibitor
tag-free photoprobe
target identification
Online Access:https://doi.org/10.3762/bjoc.9.111

Internet

https://doi.org/10.3762/bjoc.9.111

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