Recognition of Aspergillus fumigatus hyphae by human plasmacytoid dendritic cells is mediated by dectin-2 and results in formation of extracellular traps.

Recognition of Aspergillus fumigatus hyphae by human plasmacytoid dendritic cells is mediated by dectin-2 and results in formation of extracellular traps.

Plasmacytoid dendritic cells (pDCs) were initially considered as critical for innate immunity to viruses. However, our group has shown that pDCs bind to and inhibit the growth of Aspergillus fumigatus hyphae and that depletion of pDCs renders mice hypersusceptible to experimental aspergillosis. In t...

Full description

Bibliographic Details
Main Authors: Flávio V Loures, Marc Röhm, Chrono K Lee, Evelyn Santos, Jennifer P Wang, Charles A Specht, Vera L G Calich, Constantin F Urban, Stuart M Levitz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-02-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4450068?pdf=render

Internet

http://europepmc.org/articles/PMC4450068?pdf=render

Similar Items