Microbial-Host Co-metabolites Are Prodromal Markers Predicting Phenotypic Heterogeneity in Behavior, Obesity, and Impaired Glucose Tolerance

Microbial-Host Co-metabolites Are Prodromal Markers Predicting Phenotypic Heterogeneity in Behavior, Obesity, and Impaired Glucose Tolerance

The influence of the gut microbiome on metabolic and behavioral traits is widely accepted, though the microbiome-derived metabolites involved remain unclear. We carried out untargeted urine 1H-NMR spectroscopy-based metabolic phenotyping in an isogenic C57BL/6J mouse population (n = 50) and show tha...

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Bibliographic Details
Main Authors: Marc-Emmanuel Dumas, Alice R. Rothwell, Lesley Hoyles, Thomas Aranias, Julien Chilloux, Sophie Calderari, Elisa M. Noll, Noémie Péan, Claire L. Boulangé, Christine Blancher, Richard H. Barton, Quan Gu, Jane F. Fearnside, Chloé Deshayes, Christophe Hue, James Scott, Jeremy K. Nicholson, Dominique Gauguier
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Cell Reports
Subjects:
natural phenotypic variation
impaired glucose tolerance
obesity
anxiety
microbiome
metabolome
transcriptome
trimethylamine-N-oxide
TMAO
endoplasmic reticulum stress
insulin secretion
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717308537

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http://www.sciencedirect.com/science/article/pii/S2211124717308537

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