Discovery and Preliminary Characterization of Translational Modulators that Impair the Binding of eIF6 to 60S Ribosomal Subunits

Discovery and Preliminary Characterization of Translational Modulators that Impair the Binding of eIF6 to 60S Ribosomal Subunits

Eukaryotic initiation factor 6 (eIF6) is necessary for the nucleolar biogenesis of 60S ribosomes. However, most of eIF6 resides in the cytoplasm, where it acts as an initiation factor. eIF6 is necessary for maximal protein synthesis downstream of growth factor stimulation. eIF6 is an antiassociation...

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Bibliographic Details
Main Authors: Elisa Pesce, Annarita Miluzio, Lorenzo Turcano, Claudia Minici, Delia Cirino, Piera Calamita, Nicola Manfrini, Stefania Oliveto, Sara Ricciardi, Renata Grifantini, Massimo Degano, Alberto Bresciani, Stefano Biffo
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cells
Subjects:
iria
initiation
polysomes
eif4e
rack1
shwachman–diamond syndrome
eifsixty-i
Online Access:https://www.mdpi.com/2073-4409/9/1/172

Internet

https://www.mdpi.com/2073-4409/9/1/172

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