Low Z‐4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen

Low Z‐4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen

Low steady‐state levels of active tamoxifen metabolites have been associated with inferior treatment outcomes. In this retrospective analysis of 406 estrogen receptor‐positive breast cancer (BC) patients receiving adjuvant tamoxifen as initial treatment, we have associated our previously reported th...

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Bibliographic Details
Main Authors: Thomas Helland, Bjørn Naume, Steinar Hustad, Ersilia Bifulco, Jan Terje Kvaløy, Anna Barbro Sætersdal, Marit Synnestvedt, Tone Hoel Lende, Bjørnar Gilje, Ingvil Mjaaland, Kjetil Weyde, Egil Støre Blix, Gro Wiedswang, Elin Borgen, Daniel Louis Hertz, Emiel Adrianus Maria Janssen, Gunnar Mellgren, Håvard Søiland
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:Molecular Oncology
Subjects:
4OHtam
concentration threshold
endoxifen
outcomes
therapeutic drug monitoring
Online Access:https://doi.org/10.1002/1878-0261.12865

Internet

https://doi.org/10.1002/1878-0261.12865

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