FAK regulates IL-33 expression by controlling chromatin accessibility at c-Jun motifs

FAK regulates IL-33 expression by controlling chromatin accessibility at c-Jun motifs

Abstract Focal adhesion kinase (FAK) localizes to focal adhesions and is overexpressed in many cancers. FAK can also translocate to the nucleus, where it binds to, and regulates, several transcription factors, including MBD2, p53 and IL-33, to control gene expression by unknown mechanisms. We have u...

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Bibliographic Details
Main Authors: Billie G. C. Griffith, Rosanna Upstill-Goddard, Holly Brunton, Graeme R. Grimes, Andrew V. Biankin, Bryan Serrels, Adam Byron, Margaret C. Frame
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-80111-9

Internet

https://doi.org/10.1038/s41598-020-80111-9

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