Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual

Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual

Abstract Background Bone accrual impacts lifelong skeletal health, but genetic discovery has been primarily limited to cross-sectional study designs and hampered by uncertainty about target effector genes. Here, we capture this dynamic phenotype by modeling longitudinal bone accrual across 11,000 bo...

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Bibliographic Details
Main Authors: Diana L. Cousminer, Yadav Wagley, James A. Pippin, Ahmed Elhakeem, Gregory P. Way, Matthew C. Pahl, Shana E. McCormack, Alessandra Chesi, Jonathan A. Mitchell, Joseph M. Kindler, Denis Baird, April Hartley, Laura Howe, Heidi J. Kalkwarf, Joan M. Lappe, Sumei Lu, Michelle E. Leonard, Matthew E. Johnson, Hakon Hakonarson, Vicente Gilsanz, John A. Shepherd, Sharon E. Oberfield, Casey S. Greene, Andrea Kelly, Deborah A. Lawlor, Benjamin F. Voight, Andrew D. Wells, Babette S. Zemel, Kurt D. Hankenson, Struan F. A. Grant
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Genome Biology
Subjects:
Genome-wide association study
Osteoblasts
Osteogenesis
Gene mapping
Chromatin
CRISPR
Online Access:https://doi.org/10.1186/s13059-020-02207-9

Internet

https://doi.org/10.1186/s13059-020-02207-9

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