Dnmt3b catalytic activity is critical for its tumour suppressor function in lymphomagenesis and is associated with c-Met oncogenic signalling

Dnmt3b catalytic activity is critical for its tumour suppressor function in lymphomagenesis and is associated with c-Met oncogenic signalling

Background: DNA methylation regulates gene transcription in many physiological processes in mammals including development and haematopoiesis. It is catalysed by several DNA methyltransferases, including Dnmt3b that mediates both methylation-dependant and independent gene repression. Dnmt3b is critic...

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Bibliographic Details
Main Authors: Katarina Lopusna, Pawel Nowialis, Jana Opavska, Ajay Abraham, Alberto Riva, Rene Opavsky
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:EBioMedicine
Subjects:
Lymphomagenesis
DNA methyltransferase
Epigenetic
Tumour suppressor
Catalytic activity
Mouse model
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420305673

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http://www.sciencedirect.com/science/article/pii/S2352396420305673

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