Are minor alleles more likely to be risk alleles?

Are minor alleles more likely to be risk alleles?

Abstract Background Genome-wide association studies (GWASs) have revealed relationships between over 57,000 genetic variants and diseases. However, unlike Mendelian diseases, complex diseases arise from the interplay of multiple genetic and environmental factors. Natural selection has led to a high...

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Bibliographic Details
Main Authors: Takashi Kido, Weronika Sikora-Wohlfeld, Minae Kawashima, Shinichi Kikuchi, Naoyuki Kamatani, Anil Patwardhan, Richard Chen, Marina Sirota, Keiichi Kodama, Dexter Hadley, Atul J. Butte
Format: Article
Language:English
Published: BMC 2018-01-01
Series:BMC Medical Genomics
Subjects:
GWASs
Complex diseases
Minor alleles
Risk alleles
Negative natural selection
Online Access:http://link.springer.com/article/10.1186/s12920-018-0322-5

Internet

http://link.springer.com/article/10.1186/s12920-018-0322-5

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