Are minor alleles more likely to be risk alleles?
Abstract Background Genome-wide association studies (GWASs) have revealed relationships between over 57,000 genetic variants and diseases. However, unlike Mendelian diseases, complex diseases arise from the interplay of multiple genetic and environmental factors. Natural selection has led to a high...
Main Authors: | Takashi Kido, Weronika Sikora-Wohlfeld, Minae Kawashima, Shinichi Kikuchi, Naoyuki Kamatani, Anil Patwardhan, Richard Chen, Marina Sirota, Keiichi Kodama, Dexter Hadley, Atul J. Butte |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2018-01-01
|
Series: | BMC Medical Genomics |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12920-018-0322-5 |
Similar Items
-
Identification and S-genotyping of Novel S-alleles in Wild Species of Pyrus Genus
by: A. Nikzad Gharehaghaji, et al.
Published: (2015-12-01) -
Enrichment of rare alleles within epigenetic chromatin marks in the first intron
by: Shin-Sang Jo, et al.
Published: (2019-03-01) -
The Impact of Variant Allele Frequency in EGFR Mutated NSCLC Patients on Targeted Therapy
by: Alex Friedlaender, et al.
Published: (2021-03-01) -
Chorea–Acanthocytosis and the Huntington Disease Allele in an Irish Family
by: Olwen C. Murphy, et al.
Published: (2018-10-01) -
Direct Testing for Allele-Specific Expression Differences Between Conditions
by: Luis León-Novelo, et al.
Published: (2018-02-01)