Elevated urine heparanase levels are associated with proteinuria and decreased renal allograft function.

Elevated urine heparanase levels are associated with proteinuria and decreased renal allograft function.

Heparanase is an endo-β-glucuronidase that cleaves heparan sulfate side chains, leading to structural modifications that loosen the extracellular matrix barrier and associated with tumor metastasis, inflammation and angiogenesis. In addition, the highly sulfated heparan sulfate proteoglycans are imp...

Full description

Bibliographic Details
Main Authors: Itay Shafat, Amir Agbaria, Mona Boaz, Doron Schwartz, Ronny Baruch, Richard Nakash, Neta Ilan, Israel Vlodavsky, Talia Weinstein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3441528?pdf=render

Internet

http://europepmc.org/articles/PMC3441528?pdf=render

Similar Items