Mouse DC-SIGN/CD209a as Target for Antigen Delivery and Adaptive Immunity

Mouse DC-SIGN/CD209a as Target for Antigen Delivery and Adaptive Immunity

The efficacy of vaccination studies aimed at targeting antigens to human DC-SIGN (hDC-SIGN) have been notoriously difficult to study in vivo, as eight dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN) homologs have been described in mice. CD209a/SIGNR5 has bee...

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Bibliographic Details
Main Authors: Sjoerd T. T. Schetters, Laura J. W. Kruijssen, Matheus H. W. Crommentuijn, Hakan Kalay, Jordi Ochando, Joke M. M. den Haan, Juan J. Garcia-Vallejo, Yvette van Kooyk
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
CD209a
dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin
SIGNR5
vaccination
dendritic cell
antigen delivery
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00990/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00990/full

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