Integrated in silico Analyses of Regulatory and Metabolic Networks of Synechococcus sp. PCC 7002 Reveal Relationships between Gene Centrality and Essentiality

Integrated in silico Analyses of Regulatory and Metabolic Networks of Synechococcus sp. PCC 7002 Reveal Relationships between Gene Centrality and Essentiality

Cyanobacteria dynamically relay environmental inputs to intracellular adaptations through a coordinated adjustment of photosynthetic efficiency and carbon processing rates. The output of such adaptations is reflected through changes in transcriptional patterns and metabolic flux distributions that...

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Bibliographic Details
Main Authors: Hyun-Seob Song, Ryan S. McClure, Hans C. Bernstein, Christopher C. Overall, Eric A. Hill, Alexander S. Beliaev
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:Life
Subjects:
cyanobacteria
Synechococcus 7002
gene co-expression network
genome-scale metabolic network
node centrality
gene knock-out simulation
randomization test
Online Access:http://www.mdpi.com/2075-1729/5/2/1127

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http://www.mdpi.com/2075-1729/5/2/1127

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