On the Origin of Reverse Transcriptase-Using CRISPR-Cas Systems and Their Hyperdiverse, Enigmatic Spacer Repertoires

On the Origin of Reverse Transcriptase-Using CRISPR-Cas Systems and Their Hyperdiverse, Enigmatic Spacer Repertoires

Cas1 integrase is the key enzyme of the clustered regularly interspaced short palindromic repeat (CRISPR)-Cas adaptation module that mediates acquisition of spacers derived from foreign DNA by CRISPR arrays. In diverse bacteria, the cas1 gene is fused (or adjacent) to a gene encoding a reverse trans...

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Bibliographic Details
Main Authors: Sukrit Silas, Kira S. Makarova, Sergey Shmakov, David Páez-Espino, Georg Mohr, Yi Liu, Michelle Davison, Simon Roux, Siddharth R. Krishnamurthy, Becky Xu Hua Fu, Loren L. Hansen, David Wang, Matthew B. Sullivan, Andrew Millard, Martha R. Clokie, Devaki Bhaya, Alan M. Lambowitz, Nikos C. Kyrpides, Eugene V. Koonin, Andrew Z. Fire, Stephen P. Goff
Format: Article
Language:English
Published: American Society for Microbiology 2017-07-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/8/4/e00897-17

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http://mbio.asm.org/cgi/content/full/8/4/e00897-17

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