Clinical trials optimizing investigator and self‐collection of buccal cells for RNA yield

Clinical trials optimizing investigator and self‐collection of buccal cells for RNA yield

Abstract Objective Buccal cells are an ideal surrogate tissue for studying biologic effects of carcinogens or drugs, however inherent fragility and salivary RNAses limit RNA yield. We conducted healthy volunteer trials to optimize collection conditions. Methods We conducted: (a) a single‐arm crossov...

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Bibliographic Details
Main Authors: Jessica L. Geiger, Elizabeth D. Cedars, Yan Zang, Daniel P. Normolle, Hua Li, Jennifer R. Grandis, Sara Centuori, Daniel E. Johnson, Julie E. Bauman
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Laryngoscope Investigative Otolaryngology
Subjects:
biomarker
buccal cell
cytobrush
evidence‐based medicine
molecular biology
oral cavity
Online Access:https://doi.org/10.1002/lio2.516

Internet

https://doi.org/10.1002/lio2.516

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