Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase.

Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase.

Protein poly(ADP-ribosyl)ation (PARylation) regulates a number of important cellular processes. Poly(ADP-ribose) glycohydrolase (PARG) is the primary enzyme responsible for hydrolyzing the poly(ADP-ribose) (PAR) polymer in vivo. Here we report crystal structures of the mouse PARG (mPARG) catalytic d...

Full description

Bibliographic Details
Main Authors: Zhizhi Wang, Jean-Philippe Gagné, Guy G Poirier, Wenqing Xu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3897571?pdf=render

Internet

http://europepmc.org/articles/PMC3897571?pdf=render

Similar Items