CN133, a Novel Brain-Penetrating Histone Deacetylase Inhibitor, Hampers Tumor Growth in Patient-Derived Pediatric Posterior Fossa Ependymoma

CN133, a Novel Brain-Penetrating Histone Deacetylase Inhibitor, Hampers Tumor Growth in Patient-Derived Pediatric Posterior Fossa Ependymoma

Pediatric ependymoma (EPN) is a highly aggressive tumor of the central nervous system that remains incurable in 40% of cases. In children, the majority of cases develop in the posterior fossa and can be classified into two distinct molecular entities: EPN posterior fossa A (PF-EPN-A) and EPN posteri...

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Bibliographic Details
Main Authors: Roberta Antonelli, Carlos Jiménez, Misha Riley, Tiziana Servidei, Riccardo Riccardi, Aroa Soriano, Josep Roma, Elena Martínez-Saez, Maurizio Martini, Antonio Ruggiero, Lucas Moreno, Josep Sánchez de Toledo, Soledad Gallego, Jordi Bové, Jacob M. Hooker, Miguel F. Segura
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
pediatric brain tumors
posterior fossa ependymoma
epigenetic therapies
histone deacetylase inhibitors (HDACi)
Online Access:https://www.mdpi.com/2072-6694/12/7/1922

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https://www.mdpi.com/2072-6694/12/7/1922

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