Biochemical competition makes fatty-acid β-oxidation vulnerable to substrate overload.

Biochemical competition makes fatty-acid β-oxidation vulnerable to substrate overload.

Fatty-acid metabolism plays a key role in acquired and inborn metabolic diseases. To obtain insight into the network dynamics of fatty-acid β-oxidation, we constructed a detailed computational model of the pathway and subjected it to a fat overload condition. The model contains reversible and satura...

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Bibliographic Details
Main Authors: Karen van Eunen, Sereh M J Simons, Albert Gerding, Aycha Bleeker, Gijs den Besten, Catharina M L Touw, Sander M Houten, Bert K Groen, Klaas Krab, Dirk-Jan Reijngoud, Barbara M Bakker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3744394?pdf=render

Internet

http://europepmc.org/articles/PMC3744394?pdf=render

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