PROX1 is a transcriptional regulator of MMP14

PROX1 is a transcriptional regulator of MMP14

Abstract The transcription factor PROX1 is essential for development and cell fate specification. Its function in cancer is context-dependent since PROX1 has been shown to play both oncogenic and tumour suppressive roles. Here, we show that PROX1 suppresses the transcription of MMP14, a metalloprote...

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Bibliographic Details
Main Authors: Silvia Gramolelli, Jianpin Cheng, Ines Martinez-Corral, Markus Vähä-Koskela, Endrit Elbasani, Elisa Kaivanto, Ville Rantanen, Krista Tuohinto, Sampsa Hautaniemi, Mark Bower, Caj Haglund, Kari Alitalo, Taija Mäkinen, Tatiana V. Petrova, Kaisa Lehti, Päivi M. Ojala
Format: Article
Language:English
Published: Nature Publishing Group 2018-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-27739-w

Internet

https://doi.org/10.1038/s41598-018-27739-w

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