A Monosaccharide Residue Is Sufficient to Maintain Mouse and Human IgG Subclass Activity and Directs IgG Effector Functions to Cellular Fc Receptors

A Monosaccharide Residue Is Sufficient to Maintain Mouse and Human IgG Subclass Activity and Directs IgG Effector Functions to Cellular Fc Receptors

Immunoglobulin G (IgG) glycosylation modulates antibody activity and represents a major source of heterogeneity within antibody preparations. Depending on their glycosylation pattern, individual IgG glycovariants present in recombinant antibody preparations may trigger effects ranging from enhanced...

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Bibliographic Details
Main Authors: Daniela Kao, Heike Danzer, Mattias Collin, Andrea Groß, Jutta Eichler, Jerko Stambuk, Gordan Lauc, Anja Lux, Falk Nimmerjahn
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Cell Reports
Subjects:
cytotoxic antibodies
glycosylation
Fcγ receptors
IgG
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715013273

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http://www.sciencedirect.com/science/article/pii/S2211124715013273

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