Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock

Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock

Sakomoto et al. identify naphthofluorescein as a mint3 inhibitor that disrupts the Mint3–FIH-1 interaction and attenuates HIF-1 activity. In vivo experiments in mice reveal a reduction in tumor growth with attenuated inflammatory cytokine production and endotoxic shock, presenting an option for targ...

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Bibliographic Details
Main Authors: Takeharu Sakamoto, Yuya Fukui, Yasumitsu Kondoh, Kaori Honda, Takeshi Shimizu, Toshiro Hara, Tetsuro Hayashi, Yurika Saitoh, Yoshinori Murakami, Jun-ichiro Inoue, Shuichi Kaneko, Hiroyuki Osada, Motoharu Seiki
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02701-1

Internet

https://doi.org/10.1038/s42003-021-02701-1

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