Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells

Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells

Summary: Leukemia stem cells (LSCs) are believed to have more distinct vulnerabilities than the bulk acute myeloid leukemia (AML) cells, but their rarity and the lack of universal markers for their prospective isolation hamper their study. We report that genetically clonal induced pluripotent stem c...

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Bibliographic Details
Main Authors: Josephine Wesely, Andriana G. Kotini, Franco Izzo, Hanzhi Luo, Han Yuan, Jun Sun, Maria Georgomanoli, Asaf Zviran, André G. Deslauriers, Neville Dusaj, Stephen D. Nimer, Christina Leslie, Dan A. Landau, Michael G. Kharas, Eirini P. Papapetrou
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
Leukemia stem cells
iLSCs
RUNX1
LSC gene signature
AML
iPSCs
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720306410

Internet

http://www.sciencedirect.com/science/article/pii/S2211124720306410

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