RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction

by Mauro Montalbano, Salome McAllen, Nicha Puangmalai, Urmi Sengupta, Nemil Bhatt, Omar D. Johnson, Michael G. Kharas, Rakez Kayed
Published 2020-08-01

High-speed automatic characterization of rare events in flow cytometric data.

by Yuan Qi, Youhan Fang, David R Sinclair, Shangqin Guo, Meritxell Alberich-Jorda, Jun Lu, Daniel G Tenen, Michael G Kharas, Saumyadipta Pyne
Published 2020-01-01

Peptidomimetic blockade of MYB in acute myeloid leukemia

by Kavitha Ramaswamy, Lauren Forbes, Gerard Minuesa, Tatyana Gindin, Fiona Brown, Michael G. Kharas, Andrei V. Krivtsov, Scott A. Armstrong, Eric Still, Elisa de Stanchina, Birgit Knoechel, Richard Koche, Alex Kentsis
Published 2018-01-01

m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment

by Yuanming Cheng, Hanzhi Luo, Franco Izzo, Brian F. Pickering, Diu Nguyen, Robert Myers, Alexandra Schurer, Saroj Gourkanti, Jens C. Brüning, Ly P. Vu, Samie R. Jaffrey, Dan A. Landau, Michael G. Kharas
Published 2019-08-01

Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

by Sumiko Takao, Lauren Forbes, Masahiro Uni, Shuyuan Cheng, Jose Mario Bello Pineda, Yusuke Tarumoto, Paolo Cifani, Gerard Minuesa, Celine Chen, Michael G Kharas, Robert K Bradley, Christopher R Vakoc, Richard P Koche, Alex Kentsis
Published 2021-02-01

Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells

by Josephine Wesely, Andriana G. Kotini, Franco Izzo, Hanzhi Luo, Han Yuan, Jun Sun, Maria Georgomanoli, Asaf Zviran, André G. Deslauriers, Neville Dusaj, Stephen D. Nimer, Christina Leslie, Dan A. Landau, Michael G. Kharas, Eirini P. Papapetrou
Published 2020-06-01

HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells

by Diu T. T. Nguyen, Yuheng Lu, Karen L. Chu, Xuejing Yang, Sun-Mi Park, Zi-Ning Choo, Christopher R. Chin, Camila Prieto, Alexandra Schurer, Ersilia Barin, Angela M. Savino, Saroj Gourkanti, Payal Patel, Ly P. Vu, Christina S. Leslie, Michael G. Kharas
Published 2020-04-01

The Msi Family of RNA-Binding Proteins Function Redundantly as Intestinal Oncoproteins

by Ning Li, Maryam Yousefi, Angela Nakauka-Ddamba, Fan Li, Lee Vandivier, Kimberly Parada, Dong-Hun Woo, Shan Wang, Ammar S. Naqvi, Shilpa Rao, John Tobias, Ryan J. Cedeno, Gerard Minuesa, Katz Y, Trevor S. Barlowe, Alexander Valvezan, Sheila Shankar, Raquel P. Deering, Peter S. Klein, Shane T. Jensen, Michael G. Kharas, Brian D. Gregory, Zhengquan Yu, Christopher J. Lengner
Published 2015-12-01

MSI2 is required for maintaining activated myelodysplastic syndrome stem cells

by James Taggart, Tzu-Chieh Ho, Elianna Amin, Haiming Xu, Trevor S. Barlowe, Alexendar R. Perez, Benjamin H. Durham, Patrick Tivnan, Rachel Okabe, Arthur Chow, Ly Vu, Sun Mi Park, Camila Prieto, Christopher Famulare, Minal Patel, Christopher J. Lengner, Amit Verma, Gail Roboz, Monica Guzman, Virginia M. Klimek, Omar Abdel-Wahab, Christina Leslie, Stephen D. Nimer, Michael G. Kharas
Published 2016-02-01

Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

by Gerard Minuesa, Steven K. Albanese, Wei Xie, Yaniv Kazansky, Daniel Worroll, Arthur Chow, Alexandra Schurer, Sun-Mi Park, Christina Z. Rotsides, James Taggart, Andrea Rizzi, Levi N. Naden, Timothy Chou, Saroj Gourkanti, Daniel Cappel, Maria C. Passarelli, Lauren Fairchild, Carolina Adura, J. Fraser Glickman, Jessica Schulman, Christopher Famulare, Minal Patel, Joseph K. Eibl, Gregory M. Ross, Shibani Bhattacharya, Derek S. Tan, Christina S. Leslie, Thijs Beuming, Dinshaw J. Patel, Yehuda Goldgur, John D. Chodera, Michael G. Kharas
Published 2019-06-01