Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity

by Katharina Timper, Jens C. Brüning
Published 2017-06-01

Neuronal control of peripheral insulin sensitivity and glucose metabolism

by Johan Ruud, Sophie M. Steculorum, Jens C. Brüning
Published 2017-05-01

NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons

by Linda Engström Ruud, Mafalda M. A. Pereira, Alain J. de Solis, Henning Fenselau, Jens C. Brüning
Published 2020-01-01

Adipocyte dysfunction in a mouse model of polycystic ovary syndrome (PCOS): evidence of adipocyte hypertrophy and tissue-specific inflammation.

by Joseph S Marino, Jeffrey Iler, Abigail R Dowling, Streamson Chua, Jens C Bruning, Roberto Coppari, Jennifer W Hill
Published 2012-01-01

Hepatic leptin receptor expression can partially compensate for IL-6Rα deficiency in DEN-induced hepatocellular carcinoma

by Melanie J. Mittenbühler, Hans-Georg Sprenger, Sabine Gruber, Claudia M. Wunderlich, Lara Kern, Jens C. Brüning, F. Thomas Wunderlich
Published 2018-11-01

Energy imbalance alters Ca2+ handling and excitability of POMC neurons

by Lars Paeger, Andreas Pippow, Simon Hess, Moritz Paehler, Andreas C Klein, Andreas Husch, Christophe Pouzat, Jens C Brüning, Peter Kloppenburg
Published 2017-08-01

Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance.

by Jan Mauer, Bhagirath Chaurasia, Leona Plum, Thomas Quast, Brigitte Hampel, Matthias Blüher, Waldemar Kolanus, C Ronald Kahn, Jens C Brüning
Published 2010-05-01

The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach

by Suryaprakash Raichur, Bodo Brunner, Maximilian Bielohuby, Gitte Hansen, Anja Pfenninger, Bing Wang, Jens C. Bruning, Philip Just Larsen, Norbert Tennagels
Published 2019-03-01

Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance

by Elaine Xu, Mafalda M. A. Pereira, Ismene Karakasilioti, Sebastian Theurich, Mona Al-Maarri, Gunter Rappl, Ari Waisman, F. Thomas Wunderlich, Jens C. Brüning
Published 2017-05-01

Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo

by Melanie J. Mittenbühler, Katarzyna Saedler, Hendrik Nolte, Lara Kern, Jun Zhou, Shu-Bing Qian, Lydia Meder, Roland T. Ullrich, Jens C. Brüning, F. Thomas Wunderlich
Published 2020-12-01

Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and Engages a Pomc-Somatostatin-Growth Hormone Circuit

by Heiko Löhr, Simon Hess, Mafalda M.A. Pereira, Philip Reinoß, Sandra Leibold, Christel Schenkel, Claudia M. Wunderlich, Peter Kloppenburg, Jens C. Brüning, Matthias Hammerschmidt
Published 2018-05-01

GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans

by Ruth Hanssen, Alina Chloé Kretschmer, Lionel Rigoux, Kerstin Albus, Sharmili Edwin Thanarajah, Tamara Sitnikow, Corina Melzer, Oliver A. Cornely, Jens C. Brüning, Marc Tittgemeyer
Published 2021-03-01

Time-dependent assessment of stimulus-evoked regional dopamine release

by Rachel N. Lippert, Anna Lena Cremer, Sharmili Edwin Thanarajah, Clio Korn, Thomas Jahans-Price, Lauren M. Burgeno, Marc Tittgemeyer, Jens C. Brüning, Mark E. Walton, Heiko Backes
Published 2019-01-01

Insulin controls food intake and energy balance via NPY neurons

by Kim Loh, Lei Zhang, Amanda Brandon, Qiaoping Wang, Denovan Begg, Yue Qi, Melissa Fu, Rishikesh Kulkarni, Jonathan Teo, Paul Baldock, Jens C. Brüning, Gregory Cooney, Greg Neely, Herbert Herzog
Published 2017-06-01

Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance

by Eva Tsaousidou, Lars Paeger, Bengt F. Belgardt, Martin Pal, Claudia M. Wunderlich, Hella Brönneke, Ursel Collienne, Brigitte Hampel, F. Thomas Wunderlich, Marc Schmidt-Supprian, Peter Kloppenburg, Jens C. Brüning
Published 2014-11-01

Corrigendum to “Insulin controls food intake and energy balance via NPY neurons” [Mol Metabol 6 (2017) 574–584]

by Kim Loh, Lei Zhang, Amanda Brandon, Qiaoping Wang, Denovan Begg, Yue Qi, Melissa Fu, Rishikesh Kulkarni, Jonathan Teo, Paul Baldock, Jens C. Bruning, Gregory Cooney, Greg G. Neely, Herbert Herzog
Published 2017-11-01

Obesity Promotes Liver Carcinogenesis via Mcl-1 Stabilization Independent of IL-6Rα Signaling

by Sabine Gruber, Beate K. Straub, P. Justus Ackermann, Claudia M. Wunderlich, Jan Mauer, Jens M. Seeger, Hildegard Büning, Lukas Heukamp, Hamid Kashkar, Peter Schirmacher, Jens C. Brüning, F. Thomas Wunderlich
Published 2013-08-01

Hemicentin-1 is an essential extracellular matrix component of the dermal–epidermal and myotendinous junctions

by Daniela Welcker, Cornelia Stein, Natalia Martins Feitosa, Joy Armistead, Jin-Li Zhang, Steffen Lütke, Andre Kleinridders, Jens C. Brüning, Sabine A. Eming, Gerhard Sengle, Anja Niehoff, Wilhelm Bloch, Matthias Hammerschmidt
Published 2021-09-01

m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment

by Yuanming Cheng, Hanzhi Luo, Franco Izzo, Brian F. Pickering, Diu Nguyen, Robert Myers, Alexandra Schurer, Saroj Gourkanti, Jens C. Brüning, Ly P. Vu, Samie R. Jaffrey, Dan A. Landau, Michael G. Kharas
Published 2019-08-01

VEGF and GLUT1 are highly heritable, inversely correlated and affected by dietary fat intake: Consequences for cognitive function in humans

by Rita Schüler, Nicole Seebeck, Martin A. Osterhoff, Veronica Witte, Agnes Flöel, Andreas Busjahn, Alexander Jais, Jens C. Brüning, Turid Frahnow, Stefan Kabisch, Olga Pivovarova, Silke Hornemann, Michael Kruse, Andreas F.H. Pfeiffer
Published 2018-05-01