15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection.

15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection.

Cryptococcus neoformans is one of the leading causes of invasive fungal infection in humans worldwide. C. neoformans uses macrophages as a proliferative niche to increase infective burden and avoid immune surveillance. However, the specific mechanisms by which C. neoformans manipulates host immunity...

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Bibliographic Details
Main Authors: Robert J Evans, Katherine Pline, Catherine A Loynes, Sarah Needs, Maceler Aldrovandi, Jens Tiefenbach, Ewa Bielska, Rachel E Rubino, Christopher J Nicol, Robin C May, Henry M Krause, Valerie B O'Donnell, Stephen A Renshaw, Simon A Johnston
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007597

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https://doi.org/10.1371/journal.ppat.1007597

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