Exploring New Scaffolds for the Dual Inhibition of HIV-1 RT Polymerase and Ribonuclease Associated Functions

Exploring New Scaffolds for the Dual Inhibition of HIV-1 RT Polymerase and Ribonuclease Associated Functions

Current therapeutic protocols for the treatment of HIV infection consist of the combination of diverse anti-retroviral drugs in order to reduce the selection of resistant mutants and to allow for the use of lower doses of each single agent to reduce toxicity. However, avoiding drugs interactions and...

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Bibliographic Details
Main Authors: Rita Meleddu, Angela Corona, Simona Distinto, Filippo Cottiglia, Serenella Deplano, Lisa Sequeira, Daniela Secci, Alessia Onali, Erica Sanna, Francesca Esposito, Italo Cirone, Francesco Ortuso, Stefano Alcaro, Enzo Tramontano, Péter Mátyus, Elias Maccioni
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
HIV-RT
ribonuclease H
dual inhibitors
docking
putative binding
Online Access:https://www.mdpi.com/1420-3049/26/13/3821

Internet

https://www.mdpi.com/1420-3049/26/13/3821

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