Regulation of the dopaminergic system in a murine model of aromatic l-amino acid decarboxylase deficiency

Regulation of the dopaminergic system in a murine model of aromatic l-amino acid decarboxylase deficiency

Aromatic l-amino acid decarboxylase (AADC) is responsible for the syntheses of dopamine and serotonin. Children with AADC deficiency exhibit compromised development, particularly with regard to their motor functions. Currently, no animal model of AADC deficiency exists. We inserted an AADC gene muta...

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Bibliographic Details
Main Authors: Ni-Chung Lee, Yih-Dar Shieh, Yin-Hsiu Chien, Kai-Yuan Tzen, I-Shing Yu, Pin-Wen Chen, Min-Hsiu Hu, Meng-kai Hu, Shin-ichi Muramatsu, Hiroshi Ichinose, Wuh-Liang Hwu
Format: Article
Language:English
Published: Elsevier 2013-04-01
Series:Neurobiology of Disease
Subjects:
Aromatic l-amino acid decarboxylase deficiency
Mouse knock-in model
Neurotransmitter
Dopamine
Serotonin
Dyskinesia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112003889

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http://www.sciencedirect.com/science/article/pii/S0969996112003889

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