The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance.

The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance.

Reverse causality has made it difficult to establish the causal directions between obesity and prediabetes and obesity and insulin resistance. To disentangle whether obesity causally drives prediabetes and insulin resistance already in non-diabetic individuals, we utilized the UK Biobank and METSIM...

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Bibliographic Details
Main Authors: Zong Miao, Marcus Alvarez, Arthur Ko, Yash Bhagat, Elior Rahmani, Brandon Jew, Sini Heinonen, Linda Liliana Muñoz-Hernandez, Miguel Herrera-Hernandez, Carlos Aguilar-Salinas, Teresa Tusie-Luna, Karen L Mohlke, Markku Laakso, Kirsi H Pietiläinen, Eran Halperin, Päivi Pajukanta
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-09-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009018

Internet

https://doi.org/10.1371/journal.pgen.1009018

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