An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease

An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease

The optimal Aβ species to target for the potential treatment of Alzheimer’s disease has not yet been established. Here, the authors describe an in vitro assay that uses extracts from brain tissue from patients with Alzheimer’s disease, and application to human iPSC-derived neurons, to compare the ne...

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Bibliographic Details
Main Authors: Ming Jin, Brian O’Nuallain, Wei Hong, Justin Boyd, Valentina N. Lagomarsino, Tiernan T. O’Malley, Wen Liu, Charles R. Vanderburg, Matthew P. Frosch, Tracy Young-Pearse, Dennis J. Selkoe, Dominic M. Walsh
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05068-w

Internet

https://doi.org/10.1038/s41467-018-05068-w

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