Interleukin-13 Alters Tight Junction Proteins Expression Thereby Compromising Barrier Function and Dampens Rhinovirus Induced Immune Responses in Nasal Epithelium

Interleukin-13 Alters Tight Junction Proteins Expression Thereby Compromising Barrier Function and Dampens Rhinovirus Induced Immune Responses in Nasal Epithelium

Tight junctions (TJs) are intercellular structures which are essential for epithelial barrier function and play an important role in antimicrobial defense. Epithelium dysfunction and type-2-skewed inflammation are two main pathological phenomena of chronic rhinosinusitis with nasal polyps (CRSwNP)....

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Bibliographic Details
Main Authors: Zhi-Qun Huang, Jing Liu, Hsiao Hui Ong, Tian Yuan, Xiang-Min Zhou, Jun Wang, Kai Sen Tan, Vincent T. Chow, Qin-Tai Yang, Li Shi, Jing Ye, De-Yun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
chronic rhinosinusitis with nasal polyps
human nasal epithelial cells
interleukin-13
rhinovirus
tight junctions
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.572749/full

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https://www.frontiersin.org/article/10.3389/fcell.2020.572749/full

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