Gene-based analyses of the maternal genome implicate maternal effect genes as risk factors for conotruncal heart defects.

Gene-based analyses of the maternal genome implicate maternal effect genes as risk factors for conotruncal heart defects.

Congenital heart defects (CHDs) affect approximately 1% of newborns. Epidemiological studies have identified several genetically-mediated maternal phenotypes (e.g., pregestational diabetes, chronic hypertension) that are associated with the risk of CHDs in offspring. However, the role of the materna...

Full description

Bibliographic Details
Main Authors: Anshuman Sewda, A J Agopian, Elizabeth Goldmuntz, Hakon Hakonarson, Bernice E Morrow, Fadi Musfee, Deanne Taylor, Laura E Mitchell, Pediatric Cardiac Genomics Consortium
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0234357

Internet

https://doi.org/10.1371/journal.pone.0234357

Similar Items