Anti-leishmanial and structure-activity relationship of ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives

Anti-leishmanial and structure-activity relationship of ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives

A series of ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives were synthesized and tested for in vitro leishmanicidal activity against amastigotes of Leishmania amazonensis in axenical cultures and murine infected macrophages. Structure-activity relationships de...

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Bibliographic Details
Main Authors: Asunción Burguete, Yannick Estevez, Denis Castillo, Germán González, Raquel Villar, Beatriz Solano, Esther Vicente, Silvia Pérez Silanes, Ignacio Aldana, Antonio Monge, Michel Sauvain, Eric Deharo
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2008-12-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
quinoxaline
anti-leishmanial
structure-activity
Leishmaniasis
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000800006

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000800006

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