Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state

Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state

The conserved Musashi (Msi) family of RNA binding proteins are expressed in stem/progenitor and cancer cells, but generally absent from differentiated cells, consistent with a role in cell state regulation. We found that Msi genes are rarely mutated but frequently overexpressed in human cancers and...

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Bibliographic Details
Main Authors: Yarden Katz, Feifei Li, Nicole J Lambert, Ethan S Sokol, Wai-Leong Tam, Albert W Cheng, Edoardo M Airoldi, Christopher J Lengner, Piyush B Gupta, Zhengquan Yu, Rudolf Jaenisch, Christopher B Burge
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-11-01
Series:eLife
Subjects:
cancer genomic
translational regulation
alternative splicing
epithelial–mesenchymal transition
Online Access:https://elifesciences.org/articles/03915

Internet

https://elifesciences.org/articles/03915

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