Development of Complement Factor H–Based Immunotherapeutic Molecules in Tobacco Plants Against Multidrug-Resistant Neisseria gonorrhoeae

Development of Complement Factor H–Based Immunotherapeutic Molecules in Tobacco Plants Against Multidrug-Resistant Neisseria gonorrhoeae

Novel therapeutics against the global threat of multidrug-resistant Neisseria gonorrhoeae are urgently needed. Gonococci possess several mechanisms to evade killing by human complement, including binding of factor H (FH), a key inhibitor of the alternative pathway. FH comprises 20 short consensus re...

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Bibliographic Details
Main Authors: Jutamas Shaughnessy, Y Tran, Bo Zheng, Rosane B. DeOliveira, Sunita Gulati, Wen-Chao Song, James M. Maclean, Keith L. Wycoff, Sanjay Ram
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
Neisseria gonorrhoeae
gonorrhea
factor H
immunotherapeutic
Fc fusion protein
Nicotiana benthamiana
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.583305/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.583305/full

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