SPARC expression is associated with hepatic injury in rodents and humans with non-alcoholic fatty liver disease

SPARC expression is associated with hepatic injury in rodents and humans with non-alcoholic fatty liver disease

Abstract Mechanisms that control progression from simple steatosis to steato-hepatitis and fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) are unknown. SPARC, a secreted matricellular protein, is over-expressed in the liver under chronic injury. Contribution of SPARC accumulation...

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Bibliographic Details
Main Authors: Guillermo Mazzolini, Catalina Atorrasagasti, Agostina Onorato, Estanislao Peixoto, Martin Schlattjan, Jan-Peter Sowa, Svenja Sydor, Guido Gerken, Ali Canbay
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-18981-9

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https://doi.org/10.1038/s41598-017-18981-9

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