An elevated polyclonal free light chain level reflects a strong interferon signature in patients with systemic autoimmune diseases

An elevated polyclonal free light chain level reflects a strong interferon signature in patients with systemic autoimmune diseases

High amount of polyclonal free light chains (FLC) are reported in systemic autoimmune diseases (SAD) and we took advantage of the PRECISESADS study to better characterize them. Serum FLC levels were explored in 1979 patients with SAD (RA, SLE, SjS, Scl, APS, UCTD, MCTD) and 614 healthy controls. Inf...

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Bibliographic Details
Main Authors: Eléonore Bettacchioli, Christelle Le Gaffric, Margaux Mazeas, Maria Orietta Borghi, Johan Frostegard, Guillermo Barturen, Zuzanna Makowska, Sepideh Babei, Ralf Lesche, Pier Luigi Meroni, Marta E. Alarcon-Riquelme, Yves Renaudineau
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of Translational Autoimmunity
Subjects:
Autoimmune diseases
Free light chains
Autoantibodies
Interferon signature
Online Access:http://www.sciencedirect.com/science/article/pii/S2589909021000101

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http://www.sciencedirect.com/science/article/pii/S2589909021000101

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