Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo

Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo

Abstract Background Mitochondrial dysfunction has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Functional studies of mitochondrial bioenergetics have focused mostly on superoxide dismutase 1 (SOD1) mutants, and showed that mutan...

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Bibliographic Details
Main Authors: Hibiki Kawamata, Pablo Peixoto, Csaba Konrad, Gloria Palomo, Kirsten Bredvik, Meri Gerges, Federica Valsecchi, Leonard Petrucelli, John M. Ravits, Anatoly Starkov, Giovanni Manfredi
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Molecular Neurodegeneration
Subjects:
TDP-43
TAR DNA-binding protein 43
Mitochondria
Bioenergetics
Calcium
ALS
Online Access:http://link.springer.com/article/10.1186/s13024-017-0180-1

Internet

http://link.springer.com/article/10.1186/s13024-017-0180-1

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