Inducible IL-7 Hyperexpression Influences Lymphocyte Homeostasis and Function and Increases Allograft Rejection

Inducible IL-7 Hyperexpression Influences Lymphocyte Homeostasis and Function and Increases Allograft Rejection

The IL-7/IL-7R pathway is essential for lymphocyte development and disturbances in the pathway can lead to immune deficiency or T cell mediated destruction. Here, the effect of transient hyperexpression of IL-7 was investigated on immune regulation and allograft rejection under immunosuppression. An...

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Bibliographic Details
Main Authors: Maria Schreiber, Marc Weigelt, Anne Karasinsky, Konstantinos Anastassiadis, Sonja Schallenberg, Cathleen Petzold, Ezio Bonifacio, Karsten Kretschmer, Angela Hommel
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
Interleukin-7
allograft rejection
islet transplantation
Treg
immunosuppression
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00742/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00742/full

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