A model of in vitro UDP-glucuronosyltransferase inhibition by bile acids predicts possible metabolic disorders[S]
Increased levels of bile acids (BAs) due to the various hepatic diseases could interfere with the metabolism of xenobiotics, such as drugs, and endobiotics including steroid hormones. UDP-glucuronosyltransferases (UGTs) are involved in the conjugation and elimination of many xenobiotics and endogeno...
Main Authors: | Zhong-Ze Fang, Rong-Rong He, Yun-Feng Cao, Naoki Tanaka, Changtao Jiang, Kristopher W. Krausz, Yunpeng Qi, Pei-Pei Dong, Chun-Zhi Ai, Xiao-Yu Sun, Mo Hong, Guang-Bo Ge, Frank J. Gonzalez, Xiao-Chi Ma, Hong-Zhi Sun |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2013-12-01
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Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520356868 |
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