Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals

Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals

Abstract Background Metformin is a widely prescribed antihyperglycemic agent that has been also associated with multiple therapeutic effects in various diseases, including several types of malignancies. There is growing evidence regarding the contribution of the epigenetic mechanisms in reaching met...

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Bibliographic Details
Main Authors: Ilze Elbere, Ivars Silamikelis, Monta Ustinova, Ineta Kalnina, Linda Zaharenko, Raitis Peculis, Ilze Konrade, Diana Maria Ciuculete, Christina Zhukovsky, Dita Gudra, Ilze Radovica-Spalvina, Davids Fridmanis, Valdis Pirags, Helgi B. Schiöth, Janis Klovins
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Clinical Epigenetics
Subjects:
Metformin
Epigenetics
DNA methylation
White blood cells
Longitudinal study
Online Access:http://link.springer.com/article/10.1186/s13148-018-0593-x

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http://link.springer.com/article/10.1186/s13148-018-0593-x

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