WNT3A‐loaded exosomes enable cartilage repair

WNT3A‐loaded exosomes enable cartilage repair

Abstract Cartilage defects repair poorly. Recent genetic studies suggest that WNT3a may contribute to cartilage regeneration, however the dense, avascular cartilage extracellular matrix limits its penetration and signalling to chondrocytes. Extracellular vesicles actively penetrate intact cartilage....

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Bibliographic Details
Main Authors: Bethan L. Thomas, Suzanne E. Eldridge, Babak Nosrati, Mario Alvarez, Anne‐Sophie Thorup, Giovanna Nalesso, Sara Caxaria, Aida Barawi, James G. Nicholson, Mauro Perretti, Carles Gaston‐Massuet, Costantino Pitzalis, Alison Maloney, Adrian Moore, Ray Jupp, Francesco Dell'Accio
Format: Article
Language:English
Published: Taylor & Francis Group 2021-05-01
Series:Journal of Extracellular Vesicles
Subjects:
cartilage
drug delivery
exosomes
joint repair
WNT3a
Online Access:https://doi.org/10.1002/jev2.12088

Internet

https://doi.org/10.1002/jev2.12088

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