Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance [version 1; referees: 5 approved]

Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance [version 1; referees: 5 approved]

Leishmania has a plastic genome, and drug pressure can select for gene copy number variation (CNV). CNVs can apply either to whole chromosomes, leading to aneuploidy, or to specific genomic regions. For the latter, the amplification of chromosomal regions occurs at the level of homologous direct or...

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Bibliographic Details
Main Authors: Marie-Claude N. Laffitte, Philippe Leprohon, Barbara Papadopoulou, Marc Ouellette
Format: Article
Language:English
Published: F1000 Research Ltd 2016-09-01
Series:F1000Research
Subjects:
Bioinformatics
Cell Growth & Division
Cell Signaling
Cellular Death & Stress Responses
Evolutionary/Comparative Genetics
Genomics
Medical Microbiology
Microbial Evolution & Genomics
Nuclear Structure & Function
Parasitology
Online Access:http://f1000research.com/articles/5-2350/v1

Internet

http://f1000research.com/articles/5-2350/v1

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