The corrected gene proximity map for analyzing the 3D genome organization using Hi-C data
Abstract Background Genome-wide ligation-based assays such as Hi-C provide us with an unprecedented opportunity to investigate the spatial organization of the genome. Results of a typical Hi-C experiment are often summarized in a chromosomal contact map, a matrix whose elements reflect the co-locati...
Main Authors: | Cheng Ye, Alberto Paccanaro, Mark Gerstein, Koon-Kiu Yan |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-05-01
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Series: | BMC Bioinformatics |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12859-020-03545-y |
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