Genome-wide mapping indicates that p73 and p63 co-occupy target sites and have similar dna-binding profiles in vivo.

Genome-wide mapping indicates that p73 and p63 co-occupy target sites and have similar dna-binding profiles in vivo.

The p53 homologs, p63 and p73, share approximately 85% amino acid identity in their DNA-binding domains, but they have distinct biological functions.Using chromatin immunoprecipitation and high-resolution tiling arrays covering the human genome, we identify p73 DNA binding sites on a genome-wide lev...

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Bibliographic Details
Main Authors: Annie Yang, Zhou Zhu, Arminja Kettenbach, Philipp Kapranov, Frank McKeon, Thomas R Gingeras, Kevin Struhl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2904373?pdf=render

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http://europepmc.org/articles/PMC2904373?pdf=render

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