Motor and behavioral phenotype in conditional mutants with targeted ablation of cortical D1 dopamine receptor-expressing cells

Motor and behavioral phenotype in conditional mutants with targeted ablation of cortical D1 dopamine receptor-expressing cells

D1-dopamine receptors (Drd1a) are highly expressed in the deep layers of the cerebral cortex and the striatum. A number of human diseases such as Huntington disease and schizophrenia are known to have cortical pathology involving dopamine receptor expressing neurons. To illuminate their functional r...

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Bibliographic Details
Main Authors: Luning Jiang, Claire O'Leary, Hyun Ah. Kim, Clare L. Parish, Jim Massalas, John L. Waddington, Michelle E. Ehrlich, Günter Schütz, Ilse Gantois, Andrew J. Lawrence, John Drago
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Neurobiology of Disease
Subjects:
D1-dopamine receptor
Huntington disease
Targeted cell deletion
Dystonia
Schizophrenia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115000261

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http://www.sciencedirect.com/science/article/pii/S0969996115000261

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